Creme RIFM

The Creme RIFM model provides a detailed aggregate systemic and dermal exposure assessment system for fragrance compounds.


The model has data to assess exposure for consumers across Europe and the USA. The benefits to RIFM members of using this new model include:


  • Avoiding over-estimation of exposure
  • The model will replace the previous overly conservative and unrealistic methods for estimating aggregate exposure
  • Providing a solid scientific basis for IFRA limits for systemic effects
  • More accurate and realistic evaluation of fragrance ingredient exposure
    • No longer a need to assume that a fragrance ingredient is used in every consumer product at the maximum concentration level
    • No longer a need to assume that every consumer uses every single product type every day.
    • Product usage data now based on real habits and practice information
  • Reduction in the need for clinical toxicity testing and studies
    • Delivers significant resource and budget savings as these tests are time consuming and expensive
  • Satisfying the European Commission’s request for information on aggregate exposure when assessing dermal sensitisation
  • Satisfying the USA Toxic Substances Control Act (TSCA) Reform legislation that specifically asks for aggregate exposure of a chemical ingredient
  • Providing a unified approach to Chemical Safety Assessments under REACH

Creme RIFM Model Details

The Creme RIFM model includes detailed usage data for over 36,000 consumers representing the European and US populations. This robust population sample allows generation of accurate and realistic exposure results. The database contains detailed usage information on the following products:

  • Body Lotion
    • Mass Market
    • Prestige
  • Deodorant
    • Deodorant/Anti-Perspirant Spray
    • Deodorant/Anti-Perspirant Non-Spray
    • Body Spray
  • Oral Care
    • Toothpaste
    • Mouthwash
  • Cosmetic Styling
    • Lipstick
    • Liquid/Makeup Foundation
    • Hair Styling Products (non-Spray)
    • Hair Spray
  • Hydroalcoholics
    • Eau de Toilette
    • Eau de Parfum
    • After Shave / Cologne (Splash-on)
  • Shower Products
    • Shower Gel / Body Wash
    • Shampoo
    • Rinse-Off Conditioner
  • Moisturizers
    • Face Moisturizer
    • Hand Cream
  • Soaps
    • Bar Soap
    • Liquid Hand Soap
  • Air Care Products
    • Air Freshener (Aerosol)
    • Air Freshener (Plugin)
    • Scented Candles

Creme allows us to react rapidly and efficiently in a safety crisis thus protecting our customers and Unilever’s reputation. 

Bob Safford, Safety Assessment Manager, Unilever SEAC

I have been using Creme Global Software for many years as part of my work related to risk assessment of chemicals in food. Over the years my demands on the software have changed and increased, and the Creme Global team have always gone to great lengths to accommodate my requirements and provide technical support when needed. I have no hesitation in recommending Creme Global to anyone interested in modelling exposure scenarios.

Christina Tlustos, Food Safety Authority of Ireland

Discover in detail the benefits of using Creme RIFM Model

RIFM Case study