Aggregate exposure model for fragrance materials

The Research Institute for Fragrance Materials (RIFM) and Creme Global have partnered to develop an aggregate exposure model for fragrance materials that has substantially improved consumer safety and reduced the use of animal testing in the fragrance industry.

The RIFM model:

  • Reduces the need for time-consuming and expensive clinical toxicity testing, delivering significant resource and budget savings
  • Provides an alternative to animal testing
    • Satisfies the European Commission’s request for information on aggregate exposure when assessing dermal sensitization
  • Satisfies the USA Toxic Substances Control Act (TSCA) Reform legislation that specifically asks for aggregate exposure of a chemical ingredient
  • Provides a unified approach to Chemical Safety Assessments under REACH
  • Provides a solid scientific basis for IFRA limits for systemic effects
Aggregate exposure model for fragrance materials - RIFM

Discover how to use the RIFM model for new product development, product safety and regulation.


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estimates aggregate exposure to fragrance ingredients in personal care products cosmetics RIFM.
"It was a great pleasure to work with Creme Global on Recipe Management System (RMS) including calculation models and product comparisons for Bayn’s products. The team is highly skilled and professional and turned all our ideas into reality for quite a short period of time.”
Srdjan Solaja – BAYN
Srdjan Solaja

Our solutions and services for cosmetic, personal care and fragrance manufacturers.
Creme Global are world leaders in the application of data and digital technologies to the cosmetic industries including the Creme RIFM aggregate exposure model.

We work with the largest food, cosmetic and chemical brands in the world and also with main industry regulators in both the US and Europe.

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