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Baseline characteristics of the Food4Me Proof of Principle Study: a web-based randomised controlled trial of personalised nutrition in seven European countries

Improving lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing well-being. However, realising this potential will require the development, testing and implementation of much more effective behaviour change interventions than are used conventionally. Therefore, the aim of this study was to conduct a multi-centre, web-based, proof-of-principle study of personalised nutrition (PN) to determine whether providing more personalised dietary advice leads to greater improvements in eating patterns and health outcomes compared to conventional population-based advice. A total of 5,562 volunteers were screened across seven European countries; the first 1,607 participants who fulfilled the inclusion criteria were recruited into the trial. Participants were randomly assigned to one of the following intervention groups for a 6-month period: Level 0‚ÄĒcontrol group‚ÄĒreceiving conventional, non-PN advice; Level 1‚ÄĒreceiving PN advice based on dietary intake data alone; Level 2‚ÄĒreceiving PN advice based on dietary intake and phenotypic data; and Level 3‚ÄĒreceiving PN advice based on dietary intake, phenotypic and genotypic data. A total of 1,607 participants had a mean age of 39.8¬†years (ranging from 18 to 79¬†years). Of these participants, 60.9¬†% were women and 96.7¬†% were from white-European background. The mean BMI for all randomised participants was 25.5¬†kg¬†m‚ąí2, and 44.8¬†% of the participants had a BMI¬†‚Č•¬†25.0¬†kg¬†m‚ąí2. Food4Me is the first large multi-centre RCT of web-based PN. The main outcomes from the Food4Me study will be submitted for publication during 2015.

Authors: Celis-Morales C, …, E. J. Daly, Victor Akujobi, Rick O‚ÄôRiordan, et al on behalf of the Food4Me Study
Keywords: Personalised nutrition, Web-based, Phenotype, Genotype, Randomised controlled trial

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