Use of CARES NG to Conduct a Cumulative Dietary Exposure Assessment for Chlorotriazine Compounds: A Case Study

Estimation of dietary exposures to pesticide residues in agricultural and livestock commodities is critical in regulating the safe use of pesticide products. The U.S. Environmental Protection Agency (EPA) has long used the Dietary Exposure Evaluation Model-Food Commodity Intake Database (DEEM-FCID or DEEM) successfully for such purposes. Increasingly complex assessments may sometimes be desired. A particular […]

The impact of food industry reformulation, innovation and consumer preference on dietary intakes in Ireland: a probabilistic intake model

Strong evidence exists linking poor diet to increased risk of overweight, obesity and non-communicable diseases. Reformulation initiatives, whereby the food industry gradually reduces energy, sodium, sugar, fat and saturated fat content of their products, are identified as important strategies to improve dietary intakes. The analysis aimed to examine the impact of voluntary reformulation, changes to […]

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens

Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates a 10-step read-across (RAX) framework in practice. It aims at establishing a proof-of-concept for the value added by new approach methodologies (NAMs) […]

16S rRNA Based Profiling of Bacterial Communities Colonizing Bakery-Production Environments

Conventional culture-based techniques are largely inadequate in elucidating the microbiota contained in an environment, due to low recovery within a complex bacterial community. This limitation has been mitigated by the use of next-generation sequencing (NGS)-based approaches thereby facilitating the identification and classification of both culturable and uncultivable microorganisms. Amplicon targeted NGS methods, such as 16S […]

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