Publications

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Tiered refinement of consumer exposure to cosmetic ingredients

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens

The goal of this case study is to illustrate how a practical framework for RAX can be used to fill a hypothetical data gap for reproductive toxicity of the target chemical PP. Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products…
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Authors: Gladys Ouedraogo a, Camilla Alexander-White b, Dagmar Bury c, Harvey J. Clewell III d, Mark Cronin e, Tom Cull f, Matthew Dent f, Bertrand Desprez g, Ann Detroyer a, Corie Ellison h, Stefania Giammanco i, Eric Hack j, Nicola J. Hewitt k, Gerry Kenna l, Martina Klaric g, Reinhard Kreiling m, Cathy Lester n, Catherine Mahony n, Enrico Mombelli o, Jorge Naciff h, John O’Brien i, Andreas Schepky p, Sarah Tozer n, Bart van der Burg q, Barbara van Vugt-Lussenburg q, Sharon Stuard h, Cosmetics Europe
Publication date: 01/05/2022

The impact of food industry reformulation, innovation and consumer preference on dietary intakes in Ireland: a probabilistic intake model

Strong evidence exists linking poor diet to increased risk of overweight, obesity and non-communicable diseases. Reformulation initiatives, whereby the food industry gradually reduces energy, sodium, sugar, fat and saturated fat content of their products, are identified as important strategies to improve dietary intakes. The analysis aimed to examine the…
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Authors: Maeve Cushen, Noel Rogers, Rebecca Barron, Jasmin Wonik, Beata Stanek, Sandrine Pigat, Dermot Doherty, Linda Sturat-Trainor and Cronan McNamara
Publication date: 10/06/2020

Microbial Risk Ranking as “a web-based decision support system” tool [Conference Paper]

WHO estimates that more than 23 million people fall ill from eating contaminated food with bacteria, viruses, and parasitic protozoa in the European region every year, resulting in 4,654 deaths and more than 400,000 DALYs. Reducing these numbers has proven challenging because of the complex European food supply chain…
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Authors: Gopaiah Talari, Cronan McNamara, Enda Cummins, Rajat Nag, Kostas Koutsoumanis, John O’Brien
Publication date: 07/11/2022
Use of CARES NG to Conduct a Cumulative Dietary Exposure Assessment Creme Global

Use of CARES NG to Conduct a Cumulative Dietary Exposure Assessment for Chlorotriazine Compounds: A Case Study

Estimation of dietary exposures to pesticide residues in agricultural and livestock commodities is critical in regulating the safe use of pesticide products. The U.S. Environmental Protection Agency (EPA) has long used the Dietary Exposure Evaluation Model-Food Commodity Intake Database (DEEM-FCID or DEEM) successfully for such purposes. Increasingly complex assessments…
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Authors: Jason Johnson and Mark Breen
Publication date: 09/08/2021

Analysis of usage patterns and probabilistic risk assessment of personal care products in Korea

In daily life, many people use large amounts of personal care products (PCPs) on a regular basis. For determining the risk to consumers, product usage amount, frequency of use, and co-use patterns are essential information. In this study, the PCP usage patterns of Korean consumers were analyzed, and the…
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Authors: KeunOh Choi,Namkyu Lee, Yoonhee Uhm, Joo Won Kim, Eunkyung Lim, YoungJoo Lee
Publication date: 04/10/2022

The power, potential, benefits, and challenges of implementing high-throughput sequencing in foodsafety systems

The development and application of modern sequencing technologies have led to many new improvements in food safety and public health. With unprecedented resolution and big data, high-throughput sequencing (HTS) has enabled food safety specialists to sequence marker genes, whole genomes, and transcriptomes of microorganisms almost in real-time. These data…
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Authors: Behzad Imanian, John Donaghy, Tim Jackson, Sanjay Gummalla, Balasubramanian Ganesan, Robert C. Baker, Matthew Henderson, Emily K. Butler, Yingying Hong, Brendan Ring, Clare Thorp, Ramin Khaksar, Mansour Samadpour, Kahlil A. Lawless, Iain MacLaren-Lee, Heather A. Carleton, Renmao Tian, Wei Zhang & Jason Wan
Publication date: 16/08/2022
EFSA Roadmap for action for advancing aggregate exposure to chemicals in the EU

EFSA Roadmap for action for advancing aggregate exposure to chemicals in the EU

The European Food Safety Authority (EFSA) aims to efficiently conduct aggregate exposure assessments (AEAs) for chemicals using both exposure models and human biomonitoring (HBM) data by 2030. To realize this vision, EFSA has developed a comprehensive roadmap. This roadmap was created through a series of engagement and data collection…
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Authors: L. Lamon, J. Doyle, A. Paini, R. Moeller, S. Viegas, F. Cubadda, P. Hoet, A. van Nieuwenhuyse, H. Louro, M Dusinska, K.S. Galea, R. Canham, C. Martins, A. Gama, V. Teófilo, M. Diniz-da-Costa, M. João Silva, C. Ventura, P. Alvito, N. El Yamani, M. Ghosh, R.C. Duca, M. Siccardi, E. Runden-Pran, C. McNamara, P. Price
Publication date: 10/07/2024
Modelling the public health benefits of fibre fortification in the Chinese population through food reformulation

Modelling the public health benefits of fibre fortification in the Chinese population through food reformulation

Understanding the Impact of Dietary Fibre Fortification on Health in China This study provides a practical application that implicates the potential public health benefits that could be achieved with food product reformulation. Numerous studies have demonstrated that adequate consumption of dietary fibre (DF) offers multiple health benefits. However, data…
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Authors: Thomas Teh1, Yang Ying1, Noa Pereira Prada Schnor, Brian Flynn, William Goodwin, William O’Sullivan, Sandrine Pigat, John Hirsch, Lorraine Crowley, Katie Adolphus, Ieva Laurie, Kavita Karnik, Davide Risso
Publication date: 23/05/2024
Toxicology Letters Official Journal of EUROTOX

Physiologically based toxicokinetic models in aggregate exposure: A review

Exploring the application of Physiologically Based Kinetic (PBK) models in aggregate exposure (AE) assessment across different chemical classes. This literature review explores the application of Physiologically Based Kinetic (PBK) models in aggregate exposure (AE) assessment across different chemical classes. It builds on the screening of 1119 publications and the…
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Authors: L. Lamon, A. Paini, M. Siccardi, J. Doyle, C. McNamara, K.S. Galea, M. Ghosh, H. Louro, M.J. Silva, N. El Yamani , M. Dusinska, R. Moeller , R.C. Duca, . Cubadda, S. Viegas, C. Martins , P. Price
Publication date: 01/11/2025