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Authors: Comiskey Damien & Cian O’Mahony, E.J. Daly, Cronan McNamara
Publication date: 10/09/2014
Realistic estimates of chemical aggregate exposure are needed to ensure consumer safety and satisfy the requirements of regulators. In most cases, aggregate exposure is estimated simply by adding deterministic exposures from all product types containing the chemical. However, this summation will result in an unrealistically-conservative estimate since individuals vary…
Authors: Tozer Sarah, J F Nash, and E.J. Daly
Publication date: 01/09/2013
Exposure models provide critical information for risk assessment of personal care product ingredients, but there have been limited opportunities to compare exposure model predictions to observational exposure data. Urinary excretion data from a biomonitoring study in eight individuals were used to estimate minimum absorbed doses for triclosan and methyl-,…
Authors: Aylward Lesa, Giulia Vilone, Christina Cowan-Ellsberry, Jon A. Arnot, John N. Westgate, Cian O’Mahony & Sean M. Hays
Publication date: 05/12/2018
This chapter outlines probabilistic methods for assessing population dietary exposure. It discusses and makes recommendations on how to move from deterministic screening-type calculations to higher-tier, more refined calculations using probabilistic methods. The question of how to deal with variability and uncertainty in the exposure scenario input variables is covered….
Authors: Cronan McNamara, Sandrine Pigat
Publication date: 13/10/2022
In 2008, a proposal for assessing the risk of induction of skin sensitization to fragrance materials Quantitative Risk Assessment 1 (QRA1) was published. This was implemented for setting maximum limits for fragrance materials in consumer products….
Authors: Anne Marie Api, David Basketter, James Bridges, Peter Cadby, Graham Ellis, Nicola Gilmour, Helmut Greim, Peter Griem, Petra Kern, Alain Khaiat, John O’Brien, Thomas Rustemeyer, Cindy Ryan, Bob Safford, Benjamin Smith, Matthias Vey, Ian R. White
Publication date: 17/10/2020
In this publication, we demonstrate the feasibility of employing a rapid and cost-effective online survey approach to gather habits and practices for Southeast Asia, specifically Singapore. We describe the methodology and display the type of habits and practices data that can be gathered through this approach. Although certain limitations…
Authors: Siti Amelia Juraimi, John O’Brien, John Hirsh, Adam Tan, Joshua Teo, Alain Khaiat, Kim Long Yeo, Benjamin P.C. Smith
Publication date: 01/04/2023
Consumer exposure to cosmetic ingredients is estimated in a tiered manner. Simple Tier1 deterministic aggregate exposure modelling generates a worst case estimate of exposure. Tier1 assumes that a consumer uses all cosmetic products concomitantly daily, at maximum frequency, and products always contain the ingredient at the maximum allowed %…
Authors: Sarah Tozer, Camilla Alexander-White, Ripal Amin, Françoise Audebert, Catherine Barratt, John O’Brien, Tim Burke, Dagmar Bury, Hermine Dika Nguea, Myrto Dimopoulou, Sarah Farahmand, Sabrina Fritz, Elisabeth Gerber, Arianna Giusti, William Goodwin, Taryn Kirsch, Victor Oreffo, Cronan McNamara
Publication date: 01/09/2023
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